Alzheimer Desease
Eisai Announces The Start Of The First Clinical Study Of Ban2401, A Novel Monoclonal Antibody Targeting Neurotoxic Protofibrils - Eisai Co., Ltd. (Headquarters: Tokyo, Japan, President & CEO: Haruo Naito, “Eisai”) announced today the start of the first patient enrolled clinical study with BAN2401, a novel monoclonal antibody that is being developed as a potential next-generation therapeutic treatment for Alzheimer’s disease…
Protein Identified That Spurs Formation Of Alzheimer’s Plaques - In Alzheimer’s disease, the problem is beta-amyloid, a protein that accumulates in the brain and causes nerve cells to weaken and die. Drugs designed to eliminate plaques made of beta-amyloid have a fatal problem: they need to enter the brain and remove the plaques without attacking healthy brain cells…
New Study Singles Out Factors Linked To Cognitive Deficits In Type 2 Diabetes - Older adults with diabetes who have high blood pressure, walk slowly or lose their balance, or believe they’re in bad health, are significantly more likely to have weaker memory and slower, more rigid cognitive processing than those without these problems, according to a new study published by the American Psychological Association…
Fisher Scientists Discover Protein That Fuels Alzheimer’s Disease, Promising New Treatments Expected - Researchers at the Fisher Center for Alzheimer’s Disease Research laboratory published “Gamma-secretase Activating Protein is a Therapeutic Target for Alzheimer’s Disease” in Nature online. Drs. Gen He (lead author) and Paul Greengard have discovered a protein that stimulates the production of beta-amyloid, and therefore represents a major new advance in Alzheimer’s disease research…
Brain Exercises May Slow Cognitive Decline Initially, But Speed Up Dementia Later - New research shows that mentally stimulating activities such as crossword puzzles, reading and listening to the radio may, at first, slow the decline of thinking skills but speed up dementia later in old age. The research is published in the September 1, 2010, online issue of Neurology®, the medical journal of the American Academy of Neurology…
Mental Stimulation Delays The Decline In Thinking Skills, But May Accelerate Dementia Later On - Mentally stimulating activities that challenge and engage the brain, such as crossword puzzles, reading, or listening to the radio may help slow down cognitive decline - the gradual deterioration of thinking skills - but may encourage the acceleration of dementia later on during old age, says a report in Neurology, the journal of the American Academy of Neurology. Study author, Robert S…
Homewatch CareGivers Releases New “Guide To Living With Dementia” To Help Families Cope With The Numerous Issues Associated With Dementia - As part of its ongoing program to help caregivers and provide families with the information they need to make informed decisions, Homewatch CareGivers has released its latest resource, entitled “Guide to Living with Dementia. ” This new guide is available for free download from the company’s website…
Alzheimer’s Society Survey Shows Vital Need For Well-Thought Through Northern Ireland Dementia Strategy - 90 per cent of people do not think people with dementia in Northern Ireland are getting enough help and support, new research by Alzheimer’s Society found. The survey, carried out to coincide with the end of the consultation for Northern Ireland’s first dementia strategy, also found that only 13 per cent of people with dementia and their carers said they always receive high quality care…
Calling All Couch Potatoes! Walking Boosts Brain Connectivity, Function - A group of “professional couch potatoes,” as one researcher described them, has proven that even moderate exercise - in this case walking at one’s own pace for 40 minutes three times a week - can enhance the connectivity of important brain circuits, combat declines in brain function associated with aging and increase performance on cognitive tasks…
Study Shows Brain Trauma Associated With Lifelong Conditions That Affect Quality Of Life And Mortality - Traumatic brain injury, currently considered a singular event by the insurance industry and many health care providers, is instead the beginning of an ongoing process that impacts multiple organ systems and may cause or accelerate other diseases and disorders that can reduce life expectancy, according to research from the University of Texas Medical Branch at Galveston…
Debating The Success Of Alzheimer’s Research - An editorial in the journal Lancet debates the problems of drug development for Alzheimer’s disease. The feature questions why so many trials are failing at the phase 3 clinical trial stage and asks whether the animal models used prior to this are the most effective way to test the drugs…
Series Of Cognitive Tests That May Aid In Better Understanding And Treating Of Down Syndrome - Neuroscientists in the Down Syndrome Research Group at the University of Arizona have created a battery of tests that quickly aid in the assessment of the cognitive abilities of persons with Down syndrome. The UA collaborated on the development of the tests with colleagues at Johns Hopkins University and Emory University…
A Call For Major Reform In The Direction Of Alzheimer’s Treatment And Patient Care As The Boomer Generation Ages: New Book - Although a new surge of scientific research has uncovered telltale signs of Alzheimer’s disease that show up in brain scans and spinal taps, many questions remain unanswered about the clinical value of early testing and the overall direction of patient care, according to Dr. Kenneth S…
People Over 80 Often Have Mixed Pathologies In Their Brains That Account For Their Memory Loss, Confusion - Most recent studies show that elderly people over the age of 80 often have mixed pathologies in their brains that account for their memory loss and confusion. Very few senior citizens have “pure Alzheimer disease”; therefore, this terminology should be used with caution…
Insulin Resistance Increases Risk Of Alzheimer’s - New Study - Rising numbers of people who are resistant to insulin or who have type 2 diabetes may also have an increased risk of Alzheimer’s disease according to a new study published in Neurology. The study of 135 people from Hisayma in Fukuoka found that protein that clumps in the brain of people with Alzheimer’s disease was present in higher amounts in people who were insulin resistant…
Alzheimer’s Drug Discovery Foundation Funds AgeneBio To Advance Pharmacological Neural Stabilizer Technology - The Alzheimer’s Drug Discovery Foundation (ADDF) announced that it has awarded a grant of $240,000 to AgeneBio Inc. to develop a new class of small-molecules that have promise in treating amnestic mild cognitive impairment (aMCI), a neurological condition that often progresses to Alzheimer’s disease and affects more than 3 million aging Americans…
Type 2 Diabetes And Insulin Resistance Linked To Higher Alzheimer’s Disease Risk - Individuals with Type 2 diabetes or insulin resistance have a higher risk of developing Alzheimer’s disease because they are more likely to develop plaques in the brain associated with Azheimer’s, says a new report published in the medical journal Neurology, issued August 25th, 2010…
Insulin Resistance, Type 2 Diabetes Linked To Plaques Associated With Alzheimer’s Disease - People with insulin resistance and type 2 diabetes appear to be at an increased risk of developing plaques in the brain that are associated with Alzheimer’s disease, according to new research published in the August 25, 2010, issue of Neurology®, the medical journal of the American Academy of Neurology…
New Alzheimer’s Study Seeks To Find Earliest Clues To Disease Progression - Today, 5.3 million Americans are suffering from Alzheimer’s disease (AD), and every 70 seconds, another person develops this devastating disease. These numbers will continue to increase with our aging population unless new prevention and treatment strategies are discovered…
The Shriver Report™, A Woman’s Nation Takes On Alzheimer’s - Maria Shriver, whose California Women’s Conference is the preeminent forum by, for, and about American women, is joining with the Alzheimer’s Association the leader in Alzheimer’s care, support and research to release The Shriver Report: A Woman’s Nation Takes on Alzheimer’s on October 15…
Lipid Peroxides, More Sophisticated Than Their Reputation - Accumulation of lipid peroxides in the cell are associated with diseases and cellular stress. In the current issue of PNAS researchers at Helmholtz Zentrum München and the Swedish medical university Karolinska Institutet show that lipid peroxides also play an important, yet-unrecognized role in the regulation of receptor tyrosine kinases…
‘Village’ Movement And Community Health Clinics Offer Alternative Models Of Care - NPR: “The village movement dates to the 2001 founding of Beacon Hill Village in Boston. This year, the Village to Village Network launched to help other communities create their own senior support groups…
Protein Linked To Rheumatoid Arthritis Could Reduce Risk Of Alzheimer’s Disease - Alzheimer’s Society comment - A protein produced by people with rheumatoid arthritis completely reversed memory decline and dramatically reduced the progression of Alzheimer’s disease in mice. The study was published online by the Journal of Alzheimer’s Disease. Researchers from the University of Florida injected mice that had been genetically modified for Alzheimer’s disease with the protein GM-CSF…
Rheumatoid Arthritis Signaling Protein GM-CSF Reverses Alzheimer’s Disease In Mouse Model - A signaling protein released during rheumatoid arthritis dramatically reduced Alzheimer’s disease pathology and reversed the memory impairment of mice bred to develop symptoms of the neurodegenerative disease, a new study by the University of South Florida reports…
Lilly Halts Dosing In Phase III Alzheimer’s Disease Drug Trial Of Semagacestat - The Alzheimer’s Association is disappointed to learn of the negative interim results from the Phase III clinical trial of Semagacestat. People with Alzheimer’s urgently need more and better treatment options for this devastating, fatal brain disease…
